The Major Depressive Disorder (MDD) CircRNA RT-PCR Detection Kit is a real-time fluorescence quantitative PCR (RT-PCR) test for the objective, laboratory-based screening, diagnosis, and severity assessment of depression. Using a non-invasive plasma or saliva sample, the kit quantitatively measures four circular RNA (circRNA) biomarkers — circATF7IP, circPARN, circZBTB25, and circDYM — to calculate a depression score and classify severity as Normal, Mild to Moderate, or Severe.
WHY CIRCULAR RNA BIOMARKERS?
Circular RNAs (circRNAs) are a class of non-coding RNA with a stable closed-loop structure. They are highly enriched in the brain, closely associated with mental disorders, exceptionally stable, and readily detectable in blood and saliva — making them ideal objective biomarkers for major depressive disorder (MDD). By replacing subjective questionnaire-based assessment with a quantitative molecular readout, the test enables more precise, reproducible, and scalable depression screening.
KEY FEATURES
• The world's first molecular test kit for depression
• Non-invasive sampling: plasma or saliva
• Objective and quantitative — removes the subjectivity of rating scales
• High accuracy and specificity: accuracy >=90%, specificity >=95%
• Severity classification: Normal (score <20), Mild to Moderate (20-35), Severe (>=35)
• Early screening and diagnosis, mass screening, and treatment-efficacy evaluation across SSRIs/SNRIs, ketamine, TMS, and ECT
• Compatible with standard real-time PCR instruments equipped with FAM, ROX, and CY5 fluorescence channels (e.g., ABI 7500)
CLINICAL VALIDATION
Multicenter clinical studies totaling 753 valid samples — conducted at Zhongda Hospital Affiliated to Southeast University, the Third People's Hospital of Huzhou City, the Third People's Hospital of Huai'an City, and Beijing Anding Hospital — reported a 99.8% positive coincidence rate, 87.1% negative coincidence rate, 94.0% total coincidence rate, and a Kappa consistency coefficient of 0.878 against DSM-5 clinical reference criteria.
SPECIFICATIONS
• Specimen type: Plasma or Saliva
• Specification: 50 tests/box, 6 boxes/carton
• Methodology: Real-time fluorescence quantitative PCR
• Storage: PCR detection kit -20 +/-5 degC (12 months); nucleic acid extraction kit 15-25 degC (plasma 12 months / saliva 18 months)
• Two versions available: Plasma version and Saliva version
• Includes nucleic acid extraction kit and dedicated data-analysis software
TARGET POPULATIONS
Designed for hospitals, clinical laboratories, mental health centers, and screening programs serving high-risk groups including adolescents, pregnant and postpartum women, the elderly, and high-stress professionals.
Note: This test is intended for auxiliary clinical or research use. The final interpretation of results should be made by a clinician or psychological assessment expert.
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